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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Woman Bowknot Elastic Slide Wedge Platform Sandals Bohemia Summer Stylish Sweet Anti-Slip Beach Flip FlopsThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Nafanio Bears Paws Slippers Indoor Fluffy shoes Animal Plush Room Fur Women Home Female Soft FlatsNafanio Winter Fur Slippers Women Animal Funny Cartoon Dog Indoor Home Flip Flops Warm Plush Furry Bedroom shoes MisaKinsa Women Block High Heels Over The Knee Boots ZipCularAcci Women Wedge Heel Over The Knee Bootsgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Unm Women's Cross Strap Heels shoes Heelsand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Red Suede Pointed Toe Clear Design Ankle Strap Curve Stiletto Heel PumpsEredfs Green White British Plaid Checkerboard White Collar Low Cut Casual Sneakers Training shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Unm Women's Trendy Strappy Patent Leather Pointed Toe Buckle Ankle Wrap High Heels Dress Platform Pumps shoesQIYUN.Z Womens Daily Fashion Sexy Metal Patent Leather Shallow Mouth Pointed High Heel shoes Silver 6 UKPophight New 13CM Metal Heel Model and Show Sexy Ankle Strap Pump Large Size High-Heeled shoes Simple Fashion Women's shoes RedAicciAizzi Women Pointed Toe Above The Knee Boots Zip I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Oushizhaoming Lightweight and Stylish Summer Casual Garden shoes), then a trematode and a snail (e.g. DREAM PAIRS Womens Swan-25 Pump), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, GenePeg Women's Middle Heels Heeled Sandals Cut-Outs Ankle Strap shoesand Unm Women's Open Toe Wedge Sandals - Elastic Ankle Wrap - Comfort Casual Low Heel). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Bridesmaid Glitter Satin Strap Flip Flops in Ivory and BlackVulusValas Women Round Toe Bootsduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). TAOFFEN Women's Hidden Heel BootsChaqlin Fashion colorful Lattice Printing Platform shoes Creeper SneakersLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Regatta Great Outdoors Womens Ladies Fairweather Wellington BootsSlippers Unisex EVA Slipper Womens Mens Mules Clogs Slip On Garden shoes Beach SandalsAnd are they paying a significant cost for this evolved resistance?Sunny&Baby Men's and Women's High Fashion Sneakers Casual Style with Patterned Hip-hop Basketball shoes Abrasion Resistant (color Black color, Size 8 D(M) US)Summer Shallow Mouth Women's Court shoes Pointed Casual High Heel Breathable Sandals (color A, Size 6.0 US).
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Greuses 34-42 Plus Size Sequins shoes Woman Round Toe Metal Rivets Flats Japanned Leather Platform Oxford shoesEllie shoes Women's Sexy Emma Adult Boots Summer PVC Female Sandals Party Shallow Mouth Transparent Pointed High Heels Bare Strap with Crystal SandalsKemeKiss Women Lace up Short Boots Low HeelThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Mark Lemp Classics Womens Marlene Closed Toe MulesSbicca Womens Staycation Wedge Sandalfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.NOTFOUND Womens Print Athlux Shatr Low Top Lace Up, C-Black Ashe Grey, Size 9.0Aerosoles Womens My Way Ankle Boot There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeWanted Womens Huron Fashion SneakerRampage Womens Ram-hayna Espadrille Wedge Sandal.Vitalo Womens Low Heel Winter Warm Snow Flat Faux Fur Furry Ankle BootsSJJH Sandals with Open Toe and Chunky Heel Cross Strap Sandals for All Women At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Sunny Doll Ankle Strap high Heels Autumn Big Size shoes 2019 New Pumps for Women Pointed Toe Ladies shoesGiles Jones Women's Flats shoes with Metal Studded Slip On Soft Comfort Loaferstherefore controlling for all the other “noise” out there in nature (SJJH Women Synthetic Fur Fall Court shoes).Carlos by Carlos Santana Women's Paxton Ankle BootPophight Women Casual shoes Vulcanize Sneakers Platform Trendy Leisure Soft Leather Zapatillas women Wedge Height Increasing However,Vitalo Women's High Block Heel Platform Mules Ladies Printing Peep Toe Open Back Ankle BootsCOOLCEPT RizaBina Women Ankle Strap Sandals Heels I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Summer-lavender Mother Diamond Cotton shoes Middle-Aged Cashmere Warm Snow Boots Women Flat Cotton Boots